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Articles related to "active"


DNA-repair enzyme turns to translation

  • Writing in Nature, Shao et al.1 identify an unexpected role for the enzyme DNA-dependent protein kinase (DNA-PK) — a core component of the machinery for repairing DNA double-strand breaks (DSBs) — in the early steps of ribosome assembly.
  • A dimeric protein complex called KU initiates this process by binding to the broken DNA ends, then recruiting the DNA-PK catalytic subunit (DNA-PKcs) to form the active DNA-PK enzyme (Fig. 1a).
  • In the case of kinase-defective DNA-PK, the mutant enzyme’s inability to regulate its own activity gives the protein a new function, blocking the processing of precursor rRNA into mature 18S rRNA in the small-subunit processome.
  • Thus, much as DNA-PKcs recruits the DNA-cleaving enzyme Artemis during the NHEJ processing of DNA ends7, with U3, DNA-PKcs might also help to recruit specific RNA-cleaving nucleases (such as UTP24) to the small-subunit processome to cleave the precursor rRNA for ribosome construction.

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Milwaukee police investigating 'critical incident' near Molson Coors complex

  • The ATF tweeted that their Milwaukee field office is responding to the scene of an "active shooter" at the Molson Coors complex.
  • FBI Milwaukee is supporting police in the "very active scene," spokesman Leonard Peace said.
  • Mayor Tom Barrett is on the scene.
  • The CEO of Molson Coors is heading back to Milwaukee from a company conference that was taking place in Texas, according to a source familiar with the company.
  • CEO Gavin Hattersley was at the conference when he suddenly announced he was departing.

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Field Trip Psychedelics $8.5 million Series A pitch deck - Business Insider

  • There's a wave of startups working on developing FDA-approved drugs from compounds like psilocybin, one of the chief active ingredients in magic mushrooms, and various compounds in ibogaine, a naturally occurring hallucinogen, among others.
  • To that end, Toronto-based Field Trip Psychedelics recently closed an $8.5 million Series A funding round to build out a series of clinics for psychedelic therapies, first in Toronto, New York, and Los Angeles.
  • The clinics will add other treatments as research moves forward, and Levy said he hopes some of that research will be conducted at Field Trip's facility in Jamaica.
  • Levy said the fundraising process took a little under four months to close, relatively quick for a Series A round in an emerging industry.
  • Levy said what attracted investors to Field Trip is that the company is not focused exclusively on drug development and the "binary outcomes" that come with that process.

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Field Trip Psychedelics $8.5 million Series A pitch deck - Business Insider

  • There's a wave of startups working on developing FDA-approved drugs from compounds like psilocybin, one of the chief active ingredients in magic mushrooms, and various compounds in ibogaine, a naturally occurring hallucinogen, among others.
  • To that end, Toronto-based Field Trip Psychedelics recently closed an $8.5 million Series A funding round to build out a series of clinics for psychedelic therapies, first in Toronto, New York, and Los Angeles.
  • The clinics will add other treatments as research moves forward, and Levy said he hopes some of that research will be conducted at Field Trip's facility in Jamaica.
  • Levy said the fundraising process took a little under four months to close, relatively quick for a Series A round in an emerging industry.
  • Levy said what attracted investors to Field Trip is that the company is not focused exclusively on drug development and the "binary outcomes" that come with that process.

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Opera's new browser can tame your tabs

  • A new web browser from Opera launching today aims to help users get their chaotic mess of open tabs back under control.
  • In the latest release of Opera’s desktop browser (codenamed R2020), the company is introducing a new feature called “Workspaces” that allows you to organize your tabs based on different contexts — for example, workspaces for work, free time activities, personal projects, research, travel planning, and more.
  • For example, the browser extension OneTab lets you quickly close and save all your open tabs for later access.
  • And even if you do use an extension to aid with organization, it’s easy to forget you’ve saved your tabs somewhere — often, you’ll just search up the same pages again instead of restoring them.
  • While Workspaces is the major new feature in the beta browser, another addition lets you switch between open tabs easily by using the keyboard shortcut Ctrl + Tab — similar to switching applications on macOS.

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Ouch. Investment banking revenue hasn't been this weak since 2008

  • Meanwhile, Morgan Stanley is spending $13 billion to acquire online broker E-Trade in a bid to make its business model less volatile.
  • The turmoil reflects the severe financial pressure on investment banks broadly as they cope with muted volatility, IPO busts and technological disruptions to the way markets work.
  • And it lowers demand for the complex equity-trading instruments that sophisticated clients buy from investment banks during times of market turmoil.
  • For instance, Stifel, which caters to middle market firms, reported a 16% jump in investment banking revenue last year.
  • Although fixed income revenue rose last year at leading investment banks, the firms suffered a 10% decline in equities revenue, according to the Coalition report.
  • That long-running trend is forcing active investment firms to find ways to cut costs, including by demanding cheaper transaction costs from the major investment banks executing their trades.

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