Huge COVID study finds remdesivir doesn’t work—FDA grants approval anyway
- The US Food and Drug Administration on Thursday issued a full approval of the antiviral drug remdesivir for treating COVID-19—just days after a massive, global study concluded that the drug provides no benefit.
- Patients were split into three groups, each about 200 people—a group that got a 10-day course of remdesivir, a group that got a 5-day course, and a control group that got standard treatments.
- At day 11 of treatments, the group that had the 5-day course of remdesivir showed a statistically significant improvement in symptom scores compared with the control group.
- Swaminathan also noted that it was clear that the FDA did not have the Solidarity trial data when it made its decision to approve remdesivir.
- Though the comments suggest the WHO doesn’t support the FDA’s decision to approve remdesivir for treating COVID-19, WHO experts also suggested that the FDA approval may be irrelevant.
Nginx Service Mesh
- We are pleased to introduce a development release of NGINX Service Mesh (NSM), a fully integrated lightweight service mesh that leverages a data plane powered by NGINX Plus to manage container traffic in Kubernetes environments.
- NSM consists of a unified data plane for east‑west (service-to-service) traffic and a native integration of the NGINX Plus Ingress Controller for north‑south traffic, managed by a single control plane.
- The control plane is designed and optimized for the NGINX Plus data plane and defines the traffic management rules that are distributed to the NGINX Plus sidecars.
- Please try it out in your development and test environments, and submit your feedback on GitHub. To try out the NGINX Plus Ingress Controller, start your free 30-day trial today or contact us to discuss your use cases.
Mood and cognition after low LSD doses: A placebo controlled dose-effect study
- Low dose of LSD increased anxiety (5 and 20 mcg) and confusion (20 mcg).
- The main objective of the present dose-finding study was to determine the minimal dose of LSD needed to affect mood and cognition.
- A placebo-controlled within-subject study including 24 healthy participants, was conducted to assess the acute effects of three LSD doses (5, 10, and 20 mcg) on measures of cognition, mood, and subjective experience, up until 6 h after administration.
- LSD showed positive effects in the majority of observations by increasing positive mood (20 mcg), friendliness (5, 20 mcg), arousal (5 mcg), and decreasing attentional lapses (5, 20 mcg).
- Overall, the present study demonstrated selective, beneficial effects of low doses of LSD on mood and cognition in the majority of observations.
- The minimal LSD dose at which subjective and performance effects are notable is 5 mcg and the most apparent effects were visible after 20 mcg.
NASA's robot just landed on Bennu after 2 years — but its mission has only just begun
- The spacecraft spent two years circling Bennu, making detailed maps of its surface, learning as much as possible about the asteroid before the next phase of the mission: looking for somewhere safe to land.
- But because nothing in the solar system is simple, when OSIRIS-Rex got close to Bennu, it found that the asteroid was throwing small amounts of material from its surface.
- It was always going to be tricky to collect material from the surface – any attempt to land would be unlikely to succeed, because the low gravitational pull of Bennu would not grab onto a lander and hold it in place.
- Collection over, and the spacecraft backed away – hence the relief at mission control at the “back away, burn complete” message, showing that OSIRIS-Rex was moving away from the surface.
The majority of Facebook's traffic now uses QUIC and HTTP/3
- We are replacing the de facto protocol the internet has used for decades with QUIC, the latest and most radical step we’ve taken to optimize our network protocols to create a better experience for people on our services.
- QUIC has shown significant improvements in several metrics, including request errors, tail latency, response header size, and numerous others that meaningfully affect the experience of people using our apps.
- For example, a heuristic that adapted how aggressively the app requested new static content from the server was tuned in a way that created issues with QUIC.
- To address these concerns, we developed performance testing tools that allowed us to assess CPU usage and how effectively our congestion controller could utilize network resources.
- The Facebook app had a statically defined flow control limit for HTTP/2 that was implicitly tuned for TCP and did not perform well with QUIC.
COVID-19: Experts address 10 recent myths
- The likely explanation is related to the fact that people in the community have better access to testing, which increases case numbers, and treatments, which decreases death rates.
- It also does not take into account that we have seen reports of people who have experienced residual symptoms from their bouts of COVID-19, including ongoing respiratory problems, which we typically do not see in seasonal flu cases.
- Unfortunately, we have not seen clear evidence as to whether contracting and recovering from a SARS-CoV-2 infection will lead to long-term immunity that is protective.
- When many people stopped taking the measles vaccine, the herd immunity and the control that we had over the disease disappeared, leading to outbreaks of measles in the states of Washington and New York in 2019.
- This approach to infection control helps protect everyone in the community, including the people who are ill, because it preserves medical care and services for those who are sick.
The forklift truck drivers who never leave their desks
- When it comes to remote-controlled vehicles, teleoperation generally involves kitting out a car or truck with cameras and other sensors that feed information to a remote operator in a separate building.
- Some of the warehouses using Phantom Auto's technology fence-off the space where the remote-controlled forklifts work, says Mr Katz and the forklifts are also fitted with microphones so the operator can be warned should something be about to go wrong.
- Some argue that taxis and rideshare vehicles ought to be teleoperated, that way drivers could activate and remotely steer vehicles to customers when needed, rather than having to drive around a particular area of a city just hoping that someone will request a ride.
- In specialised environments where risk factors like pedestrians and communications interference can be more tightly controlled, remote-operated vehicles are already coming into use.
Hands-on with Amazon’s Luna game streaming service
- It’s starting with a library of 50 games and support for Mac, PC, Fire TV, and, in a first for a major streaming service, iOS devices — because Amazon has a web app that circumvents Apple’s controversial App Store rules.
- If you have a steady, strong Wi-Fi connection, Luna works pretty well, with little to no lag, smooth HD video, and responsive enough gameplay to enjoy even fast-paced platformers like Sonic Mania on an iPhone with a paired Bluetooth controller.
- There are two key parts to Luna’s performance that we haven’t been able to test: 4K streaming, which is listed as “coming soon,” and the Amazon Luna Controller, which can directly connect to Amazon’s servers and promises to reduce latency “by 17 to 30 milliseconds” compared to a Bluetooth controller.
Watch as NASA’s OSIRIS-REx mission attempts to grab a sample from an asteroid
- This afternoon, NASA’s OSIRIS-REx spacecraft will grab a small sample of rocks from the surface of an asteroid named Bennu zooming through space more than 200 million miles from Earth.
- It’s an ambitious task, but if it works, OSIRIS-REx may eventually return to Earth with the largest sample of material from another space body since NASA’s Apollo missions to the Moon.
- OSIRIS-REx will lightly touch the surface of Bennu with an extended robotic arm, which will then blast air onto the rocks and stir things up.
- Everything must be on autopilot for this sample grab, since OSIRIS-REx and Bennu are so far from Earth.
- The mission team hopes to get data back tonight that will verify whether the spacecraft touched the asteroid, but they won’t know until tomorrow if the vehicle actually retrieved a sample.
Google Assistant smart displays are getting dark mode and multiple account support
- Starting this week, smart displays such as the Nest Hub and those made by third-party companies will be updated with a new home screen experience: dark mode, and finally, the ability to see calendar events from more than one Google account.
- The biggest change is the new home screen, which is designed to provide contextual information to you depending on your habits and the time of day.
- Instead of the endlessly scrolling horizontal list of before, Google now divides the information into five distinct sections — time of day, Home Control, Media, Communicate, and Discover — accessible from tabs at the top of the screen.
- Finally, Google is adding one of the most requested features since the Assistant smart displays first came out: the ability to see information from both a personal and work Google account at the same time.